I have visited Rio Las Vegas several times for the world series, but the regular poker room is also much fun.
At an average night, you can expect a few no-limit tables open with some very good players. In order to win... well this might make things tough, but it is always fun to play with good players that know what's going on.
The tournaments are also good with some fun players enjoying the game with a few drinks. Cocktails come regularly, which is also a very good thing.
Kind of a mecca of poker rooms, you should visit Rio at least once if you are in town to play poker.